Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism

被引：48

作者：

Navas, S ^{[1
]}

Weiss, SR ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 08期

关键词：

D O I：

10.1128/JVI.77.8.4972-4978.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Recombinant murine coronaviruses, differing only in the spike gene and containing the strain A59 (moderately hepatotropic) and JHM (neurotropic) spike genes in the background of the JHM genome, were compared for the ability to replicate in the liver and induce hepatitis in weanling C57BL/6 mice. Interestingly, expression of the A59 spike glycoprotein within the background of the neurotropic JHM strain does not reproduce the A59 hepatotropic phenotype. Thus, the JHM genetic background plays a dominant role over the spike in the determination of hepatotropism.

引用

页码：4972 / 4978

页数：7

共 40 条

[1] CHRONIC HEPATITIS - AN UPDATE ON TERMINOLOGY AND REPORTING [J].

BATTS, KP ;

LUDWIG, J .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1995, 19 (12) :1409-1417

[2] Coronavirus pseudoparticles formed with recombinant M and E proteins induce alpha interferon synthesis by leukocytes [J].

Baudoux, P ;

Carrat, C ;

Besnardeau, L ;

Charley, B ;

Laude, H .

JOURNAL OF VIROLOGY, 1998, 72 (11) :8636-8643

[3]

Buchmeier MJ, 1999, CURR OPIN MICROBIOL, V2, P398

[4] Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus [J].

Das Sarma, J ;

Fu, L ;

Tsai, JC ;

Weiss, SR ;

Lavi, E .

JOURNAL OF VIROLOGY, 2000, 74 (19) :9206-9213

[5] Fulminant hepatic failure in murine hepatitis virus strain 3 infection: Tissue-specific expression of a novel fgl2 prothrombinase [J].

Ding, JW ;

Ning, Q ;

Liu, MF ;

Lai, A ;

Leibowitz, J ;

Peltekian, KM ;

Cole, EH ;

Fung, LS ;

Holloway, C ;

Marsden, PA ;

Yeger, H ;

Phillips, MJ ;

Levy, GA .

JOURNAL OF VIROLOGY, 1997, 71 (12) :9223-9230

[6] THE V5A13.1 ENVELOPE GLYCOPROTEIN DELETION MUTANT OF MOUSE HEPATITIS-VIRUS TYPE-4 IS NEUROATTENUATED BY ITS REDUCED RATE OF SPREAD IN THE CENTRAL-NERVOUS-SYSTEM [J].

FAZAKERLEY, JK ;

PARKER, SE ;

BLOOM, F ;

BUCHMEIER, MJ .

VIROLOGY, 1992, 187 (01) :178-188

[7]

Gallagher TM, 2001, ADV EXP MED BIOL, V494, P183

[8] Coronavirus spike proteins in viral entry and pathogenesis [J].

Gallagher, TM ;

Buchmeier, MJ .

VIROLOGY, 2001, 279 (02) :371-374

[9] Mouse hepatitis virus [J].

Haring, J ;

Perlman, S .

CURRENT OPINION IN MICROBIOLOGY, 2001, 4 (04) :462-466

[10] MHV-A59 FUSION MUTANTS ARE ATTENUATED AND DISPLAY ALTERED HEPATOTROPISM [J].

HINGLEY, ST ;

GOMBOLD, JL ;

LAVI, E ;

WEISS, SR .

VIROLOGY, 1994, 200 (01) :1-10

← 1 2 3 4 →