An approach to enantioselective 5-endo halo-lactonization reactions
被引:52
作者:
Garnier, Jean Marc
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 11, Lab Synth Organ & Methodol, UMR 8182, CNRS,Inst Chim Mol & Mat Orsay, F-91405 Orsay, FranceUniv Paris 11, Lab Synth Organ & Methodol, UMR 8182, CNRS,Inst Chim Mol & Mat Orsay, F-91405 Orsay, France
Garnier, Jean Marc
[1
]
Robin, Sylvie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 11, Lab Synth Organ & Methodol, UMR 8182, CNRS,Inst Chim Mol & Mat Orsay, F-91405 Orsay, FranceUniv Paris 11, Lab Synth Organ & Methodol, UMR 8182, CNRS,Inst Chim Mol & Mat Orsay, F-91405 Orsay, France
Robin, Sylvie
[1
]
Rousseau, Gerard
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 11, Lab Synth Organ & Methodol, UMR 8182, CNRS,Inst Chim Mol & Mat Orsay, F-91405 Orsay, FranceUniv Paris 11, Lab Synth Organ & Methodol, UMR 8182, CNRS,Inst Chim Mol & Mat Orsay, F-91405 Orsay, France
Rousseau, Gerard
[1
]
机构:
[1] Univ Paris 11, Lab Synth Organ & Methodol, UMR 8182, CNRS,Inst Chim Mol & Mat Orsay, F-91405 Orsay, France
N ligands;
iodine;
cyclization;
enantioselectivity;
lactones;
D O I:
10.1002/ejoc.200700041
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
Enantioselective lactonization of 4-substituted but-3-enoic acids using iodobis(N-methylephedrine) hexafluoroantimonate in dichloromethane at low temperatures is reported. The presence of bis(N-methylephedrine)silver(I) hexafluoroantimonate, derived from the excess amounts of N-methylephedrine and silver hexafluoroantimonate that were necessary for the generation of the iodo complex in the reaction mixture, is crucial for the success of this reaction. The different parameters of these cyclization reactions have been examined. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).