M0 AML, clinical and biologic features of the disease, including AML1 gene mutations:: a report of 59 cases by the Groupe Francais d'Hematologie Cellulaire (GFHC) and the Groupe Francais de Cytogenetique Hematologique (GFCH)

被引：53

作者：

Roumier, C

Eclache, V

Imbert, M

Davi, F

MacIntyre, E

Garand, R

Talmant, P

Lepelley, P

Lai, JL

Casasnovas, O

Maynadie, M

Mugneret, F

Bilhou-Naberra, C

Valensi, F

Radford, I

Mozziconacci, MJ

Arnoulet, C

Duchayne, E

Dastugue, N

Cornillet, P

Daliphard, S

Garnache, F

Boudjerra, N

Jouault, H

Fenneteau, O

Pedron, B

Berger, R

Flandrin, G

Fenaux, P

Preudhomme, C

机构：

[1] CHU Lille, Lab Hematol A, Lab Cytogenet, F-59037 Lille, France

[2] CHU Lille, Serv Malad Sang, F-59037 Lille, France

[3] Inst Rech Canc, INSERM, U524, Lille, France

[4] Hop Jean Verdier, Hematol Lab, Bondy, France

[5] Assistance Publ Hop Paris, Hop Henri Mondor, Paris, France

[6] Assistance Publ Hop Paris, Hop La Pitie Salpetriere, Paris, France

[7] Assistance Publ Hop Paris, Hop Necker Enfants Malad, Lab Cytogenet, Paris, France

[8] CHU Nantes, Inst Biol, Lab Hematol & Cytogenet Hematol, F-44035 Nantes 01, France

[9] CHU Dijon, Serv Hematol Biol, Unite Hematol Clin, Dijon, France

[10] CHU Dijon, Lab Cytogenet, Dijon, France

[11] CHU Bordeaux, Hematol Lab, Bordeaux, France

[12] Inst J Paoli I Calmettes, Lab Hematol Mol & Cytogenet, F-13009 Marseille, France

[13] Hop Purpan, Lab Hematol, Toulouse, France

[14] Hop Purpan, Lab Genet Hemopathies, Toulouse, France

[15] CH Reims, Lab Hematol & Cytogenet, Reims, France

[16] Assistance Publ Hop Paris, Hop Robert Debre, Paris, France

[17] Hop St Louis, IGM, INSERM, U301, Paris, France

来源：

BLOOD | 2003年 / 101卷 / 04期

关键词：

D O I：

10.1182/blood-2002-05-1474

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mutations of the AML1 gene are frequent molecular abnormalities in minimally differentiated acute myeloblastic leukemia (MO AML), a rare type of AML. In this retrospective multicenter study, morphologic, immunophenotypical, cytogenetic, and molecular features of 59 de novo MO AML cases were analyzed and correlated to AML1 mutations. Point mutations AML1 gene were observed in 16 cases (27%). They were correlated with higher white blood cell (WBC) count (P = .001), greater marrow blast involvement (P = .03), higher incidence of immunoglobulin H/T-cell receptor (IgH/TCR) gene rearrangement (P < .0001), and with a borderline significant lower incidence of complex karyotypes. In the 59 patients, FLT3 mutations were the only significant prognostic factors associated with short survival. 0 (C) 2003 by The American Society of Hematology.

引用

页码：1277 / 1283

页数：7

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