From pathogenesis to treatment of chronic lymphocytic leukaemia

被引：434

作者：

Zenz, Thorsten ^{[1
]}

Mertens, Daniel ^{[1
,2
]}

Kueppers, Ralf ^{[3
]}

Doehner, Hartmut ^{[1
]}

Stilgenbauer, Stephan ^{[1
]}

机构：

[1] Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany

[2] Cooperat Unit, Heidelberg, Germany

[3] Univ Duisburg, Essen Med Sch, Inst Cell Biol Canc Res, Essen, Germany

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 01期

关键词：

FLUDARABINE PLUS CYCLOPHOSPHAMIDE; RISK GENOMIC ABERRATIONS; VARIABLE REGION GENES; HEAVY-CHAIN MUTATIONS; TERM-FOLLOW-UP; NORMAL B-CELLS; V-H GENES; SOMATIC HYPERMUTATION; CD38; EXPRESSION; IMMUNOGLOBULIN HEAVY;

D O I：

10.1038/nrc2764

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and there is only a small proliferative compartment; however, the progressive accumulation of malignant cells will ultimately lead to symptomatic disease. Pathogenic mechanisms have been elucidated that involve multiple external (for example, microenvironmental stimuli and antigenic drive) and internal (genetic and epigenetic) events that are crucial in the transformation, progression and evolution of CLL. Our growing understanding of CLL biology is allowing the translation of targets and biological classifiers into clinical practice.

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收藏

页码：37 / 50

页数：14

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