From pathogenesis to treatment of chronic lymphocytic leukaemia

被引：434

作者：

Zenz, Thorsten ^{[1
]}

Mertens, Daniel ^{[1
,2
]}

Kueppers, Ralf ^{[3
]}

Doehner, Hartmut ^{[1
]}

Stilgenbauer, Stephan ^{[1
]}

机构：

[1] Univ Ulm, Dept Internal Med 3, D-89081 Ulm, Germany

[2] Cooperat Unit, Heidelberg, Germany

[3] Univ Duisburg, Essen Med Sch, Inst Cell Biol Canc Res, Essen, Germany

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 01期

关键词：

FLUDARABINE PLUS CYCLOPHOSPHAMIDE; RISK GENOMIC ABERRATIONS; VARIABLE REGION GENES; HEAVY-CHAIN MUTATIONS; TERM-FOLLOW-UP; NORMAL B-CELLS; V-H GENES; SOMATIC HYPERMUTATION; CD38; EXPRESSION; IMMUNOGLOBULIN HEAVY;

D O I：

10.1038/nrc2764

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic lymphocytic leukaemia (CLL) has several unique features that distinguish it from other cancers. Most CLL tumour cells are inert and arrested in G0/G1 of the cell cycle and there is only a small proliferative compartment; however, the progressive accumulation of malignant cells will ultimately lead to symptomatic disease. Pathogenic mechanisms have been elucidated that involve multiple external (for example, microenvironmental stimuli and antigenic drive) and internal (genetic and epigenetic) events that are crucial in the transformation, progression and evolution of CLL. Our growing understanding of CLL biology is allowing the translation of targets and biological classifiers into clinical practice.

引用

收藏

页码：37 / 50

页数：14

相关论文

共 153 条

[61] BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells [J].

Guarini, Anna ;

Chiaretti, Sabina ;

Tavolaro, Simona ;

Maggio, Roberta ;

Peragine, Nadia ;

Citarella, Franca ;

Ricciardi, Maria Rosaria ;

Santangelo, Simona ;

Marinelli, Marilisa ;

De Propris, Maria Stefania ;

Messina, Monica ;

Mauro, Francesca Romana ;

Del Giudice, Ilaria ;

Foa, Robert .

BLOOD, 2008, 112 (03) :782-792

[62] Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin VHDJH gene diversification [J].

Gurrieri, C ;

McGuire, P ;

Zan, H ;

Yan, XJ ;

Cerutti, A ;

Albesiano, E ;

Allen, SL ;

Vinciguerra, V ;

Rai, KR ;

Ferrarini, M ;

Casali, P ;

Chiorazzi, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (05) :629-639

[63] Evidence for the significant role of immunoglobulin light chains in antigen recognition and selection in chronic lymphocytic leukemia [J].

Hadzidimitriou, Anastasia ;

Darzentas, Nikos ;

Murray, Fiona ;

Smilevska, Tanja ;

Arvaniti, Eleni ;

Tresoldi, Cristina ;

Tsaftaris, Athanasios ;

Laoutaris, Nikolaos ;

Anagnostopoulos, Achilles ;

Davi, Frederic ;

Ghia, Paolo ;

Rosenquist, Richard ;

Stamatopoulos, Kostas ;

Belessi, Chrysoula .

BLOOD, 2009, 113 (02) :403-411

[64] Comprehensive genetic characterization of CLL:: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgVH status and immunophenotyping [J].

Haferlach, C. ;

Dicker, F. ;

Schnittger, S. ;

Kern, W. ;

Haferlach, T. .

LEUKEMIA, 2007, 21 (12) :2442-2451

[65] Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia:: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines [J].

Hallek, Michael ;

Cheson, Bruce D. ;

Catovsky, Daniel ;

Caligaris-Cappio, Federico ;

Dighiero, Guillaume ;

Doehner, Hartmut ;

Hillmen, Peter ;

Keating, Michael J. ;

Montserrat, Emili ;

Rai, Kanti R. ;

Kipps, Thomas J. .

BLOOD, 2008, 111 (12) :5446-5456

[66] Determination of how many immunoglobulin variable region heavy chain mutations are allowable in unmutated chronic lymphocytic leukaemia - long-term follow up of patients with different percentages of mutations [J].

Hamblin, Terry J. ;

Davis, Zadie A. ;

Oscier, David G. .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 140 (03) :320-323

[67] Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia [J].

Hamblin, TJ ;

Davis, Z ;

Gardiner, A ;

Oscier, DG ;

Stevenson, FK .

BLOOD, 1999, 94 (06) :1848-1854

[68] SOMATIC DIVERSIFICATION AND SELECTION OF IMMUNOGLOBULIN HEAVY AND LIGHT-CHAIN VARIABLE REGION GENES IN IGG(+)CD5(+) CHRONIC LYMPHOCYTIC-LEUKEMIA B-CELLS [J].

HASHIMOTO, S ;

DONO, M ;

WAKAI, M ;

ALLEN, SL ;

LICHTMAN, SM ;

SCHULMAN, P ;

VINCIGUERRA, VP ;

FERRARINI, M ;

SILVER, J ;

CHIORAZZI, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (04) :1507-1517

[69] Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity [J].

Hervé, M ;

Xu, K ;

Ng, YS ;

Wardemann, H ;

Albesiano, E ;

Messmer, BT ;

Chiorazzi, N ;

Meffre, E .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) :1636-1643

[70] Rel A Is an Independent Biomarker of Clinical Outcome in Chronic Lymphocytic Leukemia [J].

Hewamana, Saman ;

Lin, Thet Thet ;

Rowntree, Clare ;

Karunanithi, Kamaraj ;

Pratt, Guy ;

Hills, Robert ;

Fegan, Chris ;

Brennan, Paul ;

Pepper, Chris .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (05) :763-769

← 2 3 4 5 6 7 8 9 10 11 →