Pasteurella multocida capsule:: composition, function and genetics

被引：50

作者：

Boyce, JD ^{[1
]}

Chung, JY ^{[1
]}

Adler, B ^{[1
]}

机构：

[1] Monash Univ, Dept Microbiol, Clayton, Vic 3168, Australia

来源：

JOURNAL OF BIOTECHNOLOGY | 2000年 / 83卷 / 1-2期

基金：

澳大利亚研究理事会;

关键词：

Pasteurell multocida; capsule biosynthesis; polysaccharide composition; virulence;

D O I：

10.1016/S0168-1656(00)00309-6

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pasteurella multocida is an important animal pathogen and many strains express a polysaccharide capsule. The antigenicity of the capsule can be used to identify five serogroups A, B, D, E and F. Disease predilection is generally related to serogroup, with haemorrhagic septicaemia strains belonging to serogroups B or E and fowl cholera strains to serogroup A. The importance of the capsule in virulence has been implicated in a number of studies but these studies have been hampered by a lack of isogenic strains and an understanding of capsule biosynthesis at the molecular level. Recently, the nucleotide sequences and genetic organisation of the capsule biosynthetic loci have been determined for strains of P. multocida serogroups A and B. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：153 / 160

页数：8

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