Cord blood transplantation in patients with hemoglobinopathies

被引：17

作者：

Boncimino, Agata ^{[1
]}

Bertaina, Alice ^{[1
]}

Locatelli, Franco ^{[1
]}

机构：

[1] Univ Pavia, Fdn IRCCS Policlin San Matteo, I-27100 Pavia, Italy

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2010年 / 42卷 / 03期

关键词：

BONE-MARROW-TRANSPLANTATION; SICKLE-CELL-DISEASE; VERSUS-HOST-DISEASE; BETA-THALASSEMIA MAJOR; SEVERE APLASTIC-ANEMIA; MIXED CHIMERISM; FETAL-HEMOGLOBIN; RISK-FACTORS; STEM-CELLS; CHILDREN;

D O I：

10.1016/j.transci.2010.03.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite the optimization of conventional treatment, both thalassemia and sickle cell disease are still associated with significant morbidity and mortality, especially in developing countries. Allogeneic transplantation of hematopoietic progenitors is the only curative treatment and represents an attractive option for these patients. In view of the low incidence of graft-versus-host disease associated with the procedure, allogeneic cord blood transplantation (CBT) is particularly appealing for patients with non-malignant disorders. Available evidence indicates that related donor CBT is a safe and effective option for patients with hemoglobinopathies, able to offer results at least as good as those reported using bone marrow cells. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：277 / 281

页数：5

共 50 条

[1] Long-term survive of ex-thalassemic patients with persistent mixed chimerism after bone marrow transplantation [J].

Andreani, M ;

Nesci, S ;

Lucarelli, G ;

Tonucci, P ;

Rapa, S ;

Angelucci, E ;

Persini, B ;

Agostinelli, F ;

Donati, M ;

Manna, M .

BONE MARROW TRANSPLANTATION, 2000, 25 (04) :401-404

[2] Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia [J].

Andreani, M ;

Manna, M ;

Lucarelli, G ;

Tonucci, P ;

Agostinelli, F ;

Ripalti, M ;

Rapa, S ;

Talevi, N ;

Galimberti, M ;

Nesci, S .

BLOOD, 1996, 87 (08) :3494-3499

[3] Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease [J].

Bernaudin, Francoise ;

Socie, Gerard ;

Kuentz, Mathieu ;

Chevret, Sylvie ;

Duval, Michel ;

Bertrand, Yves ;

Vannier, Jean-Pierre ;

Yakouben, Karima ;

Thuret, Isabelle ;

Bordigoni, Pierre ;

Fischer, Alain ;

Lutz, Patrick ;

Stephan, Jean-Louis ;

Dhedin, Nathalie ;

Plouvier, Emmanuel ;

Margueritte, Genevieve ;

Bories, Dominique ;

Verlhac, Suzanne ;

Esperou, Helene ;

Coic, Lena ;

Vernant, Jean-Paul ;

Gluckman, Eliane .

BLOOD, 2007, 110 (07) :2749-2756

[4] Survival and disease complications in thalassemia major [J].

Borgna-Pignatti, C ;

Rugolotto, S ;

De Stefano, P ;

Piga, A ;

Di Gregorio, F ;

Gamberini, MR ;

Sabato, V ;

Melevendi, C ;

Cappellini, MD ;

Verlato, G .

COOLEYS ANEMIA: SEVENTH SYMPOSIUM, 1998, 850 :227-231

[5] Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major [J].

Borgna-Pignatti, C ;

Cappellini, MD ;

De Stefano, P ;

Del Vecchio, GC ;

Forni, GL ;

Gamberini, MR ;

Ghilardi, R ;

Piga, A ;

Romeo, MA ;

Zhao, HQ ;

Cnaan, A .

BLOOD, 2006, 107 (09) :3733-3737

[6]

Borgna-Pignatti C, 2004, HAEMATOLOGICA, V89, P1187

[7] Persistence of fetal hemoglobin production after successful transplantation of cord blood stem cells in a patient with sickle cell anemia [J].

Brichard, B ;

Vermylen, C ;

Ninane, J ;

Cornu, G .

JOURNAL OF PEDIATRICS, 1996, 128 (02) :241-243

[8] Ethical reappraisal of 15 years of cord-blood transplantation [J].

Burgio, GR ;

Gluckman, E ;

Locatelli, F .

LANCET, 2003, 361 (9353) :250-252

[9] A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with β-thalassemia [J].

Cappellini, MD ;

Cohen, A ;

Piga, A ;

Bejaoui, M ;

Perrone, S ;

Agaoglu, L ;

Aydinok, Y ;

Kattamis, A ;

Kilinc, Y ;

Porter, J ;

Capra, M ;

Galanello, R ;

Fattoum, S ;

Drelichman, G ;

Magnano, C ;

Verissimo, M ;

Athanassiou-Metaxa, M ;

Giardina, P ;

Kourakli-Symeonidis, A ;

Janka-Schaub, G ;

Coates, T ;

Vermylen, C ;

Olivieri, N ;

Thuret, I ;

Opitz, H ;

Ressayre-Djaffer, C ;

Marks, P ;

Alberti, D .

BLOOD, 2006, 107 (09) :3455-3462

[10] Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study [J].

Eapen, Mary ;

Rubinstein, Pablo ;

Zhang, Mei-Jie ;

Stevens, Cladd ;

Kurtzberg, Joanne ;

Scaradavou, Andromachi ;

Loberiza, Fausto R. ;

Champlin, Richard E. ;

Klein, John P. ;

Horowitz, Mary M. ;

Wagner, John E. .

LANCET, 2007, 369 (9577) :1947-1954

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