Potential role of CagA in the inhibition of T cell reactivity in Helicobacter pylori infections

被引：59

作者：

Paziak-Domanska, B ^{[1
]}

Chmiela, M ^{[1
]}

Jarosinska, A ^{[1
]}

Rudnicka, W ^{[1
]}

机构：

[1] Univ Lodz, Dept Infect Biol, Inst Microbiol & Immunol, PL-90237 Lodz, Poland

来源：

CELLULAR IMMUNOLOGY | 2000年 / 202卷 / 02期

关键词：

Helicobacter pylori; CagA; T cell proliferation;

D O I：

10.1006/cimm.2000.1654

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The pathogenicity of chronic gastroduodenal diseases is very often related to Helicobacter pylori infections. Most H. pylori strains carry the cagA gene encoding an immunodominant 120- to 128-kDa protein which is considered a virulence marker. The majority of CagA-positive H. pylori isolates also produce a 95-kDa protein cytotoxin (VacA) causing vacuolation and degradation of mammalian cells. In our previous study we have shown that live H. pylori bacteria and their sonicates inhibit PHA-driven proliferation of human T lymphocytes. The H. pylori CagA and VacA proteins were suspected of a paralyzing effect of H. pylori on T cell proliferation. In this report, by using isogenic H. pylori mutant strains defective in CagA and VacA proteins, we determined that CagA is responsible for the inhibition of PHA-induced proliferation of T cells. (C) 2000 Academic Press.

引用

页码：136 / 139

页数：4

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