Disruption of amyloid-derived peptide assemblies through the controlled induction of a β-sheet to α-helix transformation:: Application of the switch concept

被引：55

作者：

Mimna, Richard

Camus, Marie-Stephanie

Schmid, Adrian

Tuchscherer, Gabriele

Lashuel, Hilal A. ^{[1
]}

Mutter, Manfred

机构：

[1] Ecole Polytech Fed Lausanne, Brain Mind Inst, CH-1015 Lausanne, Switzerland

[2] Eidgenoss TH Lausanne, EPFL, Inst Chem Sci & Engn ISIC, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 15期

关键词：

amyloid fibrils; conformational transitions; fibril disruption; neurodegenerative diseases; switch peptides;

D O I：

10.1002/anie.200603681

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Most problems are soluble: Reversal of amyloid formation through a controlled induced transformation from β-sheet to soluble α-helix structures through the use of a switch element S (see scheme, σ is a helix-inducing template) could have an important consequences understanding the mechanisms of amyloid formation and clearance. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：2681 / 2684

页数：4

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