New molecular players in capacitative Ca2+ entry

被引:131
作者
Putney, James W., Jr. [1 ]
机构
[1] NIEHS, NIH, Res Triangle Pk, NC 27709 USA
关键词
store-operated Ca2+ entry; Ca2+ channels; Stim1; Orai1; Ca2+-release; activated Ca2+ current;
D O I
10.1242/jcs.03462
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Capacitative Ca2+ entry links the emptying of intracellular Ca2+ stores to the activation of store-operated Ca2+ channels in the plasma membrane. In the twenty years since the inception of the concept of capacitative Ca2+ entry, a number of activation mechanisms have been proposed, and there has been considerable interest in the possibility that TRP channels function as store- operated channels. However, in the past two years, two major players in both the signaling and permeation mechanisms for storeoperated channels have been discovered: Stim1 and the Orai proteins. Stim1 is an endoplasmic reticulum Ca2+ sensor. It appears to act by redistributing within a small component of the endoplasmic reticulum, approaching the plasma membrane, but does not seem to translocate into the plasma membrane. Stim1 signals to plasma membrane Orai proteins, which constitute pore-forming subunits of store-operated channels.
引用
收藏
页码:1959 / 1965
页数:7
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