When ELFs are ORFs, but don't act like them

被引:17
作者
Lawrence, J [1 ]
机构
[1] Univ Pittsburgh, Pittsburgh Bacteriophage Inst, Pittsburgh, PA 15260 USA
[2] Univ Pittsburgh, Dept Biol Sci, Pittsburgh, PA 15260 USA
关键词
D O I
10.1016/S0168-9525(02)00038-0
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
When they are very small, open reading frames (ORFs) are among the most difficult features of a newly sequenced genome to annotate. Although it has been suggested that degree of conservation of these sequences among closely related genomes might assist this process, there are some classes of ORF that will defy identification because little or none of the protein sequence is under selection.
引用
收藏
页码:131 / 132
页数:2
相关论文
共 9 条
[1]   Analysis of tryptophanase operon expression in vitro -: Accumulation of TnaC-peptidyl-tRNA in a release factor 2-depleted S-30 extract prevents Rho factor action, simulating induction [J].
Gong, F ;
Yanofsky, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (19) :17095-17100
[2]   Ribosome regulation by the nascent peptide [J].
Lovett, PS ;
Rogers, EJ .
MICROBIOLOGICAL REVIEWS, 1996, 60 (02) :366-+
[3]   NUCLEOTIDE-SEQUENCE AND STRUCTURE OF THE KLEBSIELLA-PNEUMONIAE PQQ OPERON [J].
MEULENBERG, JJM ;
SELLINK, E ;
RIEGMAN, NH ;
POSTMA, PW .
MOLECULAR AND GENERAL GENETICS, 1992, 232 (02) :284-294
[4]   Distinguishing the ORFs from the ELFs: short bacterial genes and the annotation of genomes [J].
Ochman, H .
TRENDS IN GENETICS, 2002, 18 (07) :335-337
[5]  
PIERARD A, 1978, J BACTERIOL, V134, P167
[6]   ROLE OF LEADER PEPTIDE-SYNTHESIS IN TRYPTOPHANASE OPERON EXPRESSION IN ESCHERICHIA-COLI K-12 [J].
STEWART, V ;
YANOFSKY, C .
JOURNAL OF BACTERIOLOGY, 1986, 167 (01) :383-386
[7]   SYNTHESIS OF PYRROLOQUINOLINE QUINONE IN-VIVO AND IN-VITRO AND DETECTION OF AN INTERMEDIATE IN THE BIOSYNTHETIC-PATHWAY [J].
VELTEROP, JS ;
SELLINK, E ;
MEULENBERG, JJM ;
DAVID, S ;
BULDER, I ;
POSTMA, PW .
JOURNAL OF BACTERIOLOGY, 1995, 177 (17) :5088-5098
[8]   Identification of novel small RNAs using comparative genomics and microarrays [J].
Wassarman, KM ;
Repoila, F ;
Rosenow, C ;
Storz, G ;
Gottesman, S .
GENES & DEVELOPMENT, 2001, 15 (13) :1637-1651
[9]  
YANOFSKY C, 1988, J BIOL CHEM, V263, P609