Distinguishing the ORFs from the ELFs: short bacterial genes and the annotation of genomes

被引：60

作者：

Ochman, H ^{[1
]}

机构：

[1] Univ Arizona, Dept Biochem & Mol Biophys, Tucson, AZ 85721 USA

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 07期

关键词：

D O I：

10.1016/S0168-9525(02)02668-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A substantial fraction of hypothetical open reading frames (ORFs) in completely sequenced bacterial genomes are short, suggesting that many are not genes but random stretches of DNA. Although it is not feasible to authenticate the coding capacity of all such regions experimentally, comparisons of ORFs in related genomes can expose those that encode functional proteins.

引用

页码：335 / 337

页数：3

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