Genetics of polycystic ovarian syndrome

被引：18

作者：

Menke, Marie Nam

Strauss, Jerome F., III

机构：

[1] Virginia Commonwealth Univ Hlth Syst, Dept Obstet & Gynecol, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Sch Med, Richmond, VA USA

来源：

CLINICAL OBSTETRICS AND GYNECOLOGY | 2007年 / 50卷 / 01期

关键词：

PCOS; candidate genes; complex disorder; linkage analysis; association studies; reproductive medicine; women's health;

D O I：

10.1097/GRF.0b013e3180305f7c

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Polycystic ovarian syndrome is a complex disorder with multiple factors affecting its etiology. Elucidation of specific genes and mode of inheritance remains a significant challenge. Linkage and association studies have resulted in over 50 candidate genes as a source of heritable predisposition; however, small sample sizes and failure to reproduce results have hindered efforts. In addition, low fecundity, lack of a male phenotype, and variation of diagnostic criteria represent unique challenges to discovery of polycystic ovarian syndrome genes. A concerted effort will be necessary to conclusively rule in or rule out candidate genes.

引用

收藏

页码：188 / 204

页数：17

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