Diastereoselective intramolecular nitroaldol entry to lycoricidine alkaloids

被引：42

作者：

McNulty, J ^{[1
]}

Mo, RW ^{[1
]}

机构：

[1] Brock Univ, Dept Chem, St Catharines, ON L2S 3A1, Canada

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 08期

关键词：

D O I：

10.1039/a800097b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The alumina promoted 6-exo-trig intramolecular nitroaldol cyclization described proceeds in a highly diastereoselective manner via a proposed chelation controlled chair-like transition state, the major diastereomer having the correct relative configuration at three stereocentres as observed in the pancratistatin series of antitumor agents, in contrast to prior literature cyclization methods.

引用

页码：933 / 934

页数：2

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