SYNTHESIS OF PANCRATISTATIN MODELS

被引：41

作者：

LOPES, RSC ^{[1
]}

LOPES, CC ^{[1
]}

HEATHCOCK, CH ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY, DEPT CHEM, BERKELEY, CA 94720 USA

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 45期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(00)61773-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two model syntheses for the phenanthridone core of the cytotoxic alkaloid pancratistatin are reported. The key maneuver in these syntheses is 1,4-addition of an ortho-lithiated benzamide derivative to 1-nitrocyclohexene. The resulting 2-aryl-1-nitrocyclohexanes (6 and 11) are further transformed into the pancratistatin models 2 and 3.

引用

页码：6775 / 6778

页数：4

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