A facile method for the preparation of deuterium labeled salvinorin A:: synthesis of [2,2,2-2H3]-salvinorin A

被引：54

作者：

Tidgewell, K

Harding, WW

Schmidt, M

Holden, KG

Murry, DJ

Prisinzano, TE ^{[1
]}

机构：

[1] Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Pharm, Div Clin & Adm Pharm, Iowa City, IA 52242 USA

[3] Holden Labs, Carmel, CA 93923 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 20期

关键词：

salvinorin A; deuterium; Salvia divinorum; hallucinogen;

D O I：

10.1016/j.bmcl.2004.07.081

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Salvinorin A is a novel hallucinogen isolated from the widely available leaves of Salvia divinorum. Based on its mechanism of action, salvinorin A has shown potential as a stimulant abuse therapeutic. However, there are no methods for the detection of salvinorin A or its metabolites in biological fluids. In order to begin developing salvinorin A as a potential therapeutic, an understanding of its metabolism is needed. Here, a straightforward synthesis of a deuterium labeled analog of salvinorin A and its utility as an internal standard for the detection of salvinorin A and its metabolites in biological fluids by LC-MS is described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5099 / 5102

页数：4

共 18 条

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