Automated synthesis of 6-[18F]fluoro-L-DOPA using modified polystyrene supports with bound 6-mercuric DOPA precursors

被引：17

作者：

Szajek, LP ^{[1
]}

Channing, MA ^{[1
]}

Eckelman, WC ^{[1
]}

机构：

[1] NIH, Warren Grant Magnuson Clin Ctr, PET Dept, Bethesda, MD 20892 USA

来源：

APPLIED RADIATION AND ISOTOPES | 1998年 / 49卷 / 07期

关键词：

D O I：

10.1016/S0969-8043(97)00304-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Polystyrene polymer substrates were prepared having protected L-DOPA precursors mercurated in the 6-position. When treated with gaseous [F-18]acetyl hypofluorite followed by HI hydrolysis, 6-[F-18]fluoro-3,4-dihydroxy-L-phenylalanine (6-[F-18]fluoro-L-DOPA) was obtained in 2-23% overall chemical yield. The highest yield was obtained using P-CH2CO2Hg(pro-DOPA), where P = polystyrene and pro-DOPA is protected L-DOPA. These modified polystyrene supports are easily prepared, require no special storage treatment, and are convenient to use in an automated 6-[F-18]fluoro-L-DOPA production system. Published by Elsevier Science Ltd.

引用

页码：795 / 804

页数：10

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