Calcium regulation of basic helix-loop-helix transcription factors

被引：31

作者：

Hermann, S ^{[1
]}

Saarikettu, J ^{[1
]}

Onions, J ^{[1
]}

Hughes, K ^{[1
]}

Grundström, T ^{[1
]}

机构：

[1] Umea Univ, Dept Cell & Mol Biol, Div Tumour Biol, S-90187 Umea, Sweden

来源：

CELL CALCIUM | 1998年 / 23卷 / 2-3期

基金：

瑞典研究理事会;

关键词：

D O I：

10.1016/S0143-4160(98)90112-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The basic helix-loop-helix (bHLH) family of transcription factors is essential for numerous developmental and growth control processes. The regulation of bHLH proteins occurs at many levels, including tissue specific expression, differential oligomerization and DNA binding specificities, interaction with negatively acting HLH proteins and post-translational modifications. This review focuses on what is emerging as another level of bHLH protein regulation, calcium regulation through interaction with Ca2+ loaded calmodulin and S-100 proteins. The mechanism and implications of these Ca2+ regulated interactions are discussed.

引用

页码：135 / 142

页数：8

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