New natural intergenotypic (2/5) recombinant of hepatitis C virus

被引：95

作者：

Legrand-Abravanel, Florence ^{[1
]}

Claudinon, Julie ^{[1
]}

Nicot, Florence ^{[1
]}

Dubois, Martine ^{[1
]}

Chapuy-Regaud, Sabine ^{[1
]}

Sandres-Saune, Karine ^{[1
]}

Pasquier, Christophe ^{[1
]}

Izopet, Jacques ^{[1
]}

机构：

[1] INSERM, U563, IFR 30, Inst Federatif Biol,Lab Virol, F-31059 Toulouse 9, France

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 08期

关键词：

D O I：

10.1128/JVI.02639-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A 9.2-kb sequence from a hepatitis C virus (HCV) strain found in southwest France was compared to sequences from reference strains in HCV sequence databases. We found a recombinant virus with genotype 2 at the 5' end and genotype 5 at the 3' end. The crossover point was located between genes NS2 and NS3. Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy. Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses.

引用

页码：4357 / 4362

页数：6

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