Adaptive immunity and atherosclerosis

被引：218

作者：

Andersson, John ^{[1
]}

Libby, Peter ^{[2
,3
,4
]}

Hansson, Goran K. ^{[1
,2
,3
]}

机构：

[1] Karolinska Univ Hosp, Ctr Mol Med, Dept Med, Karolinska Inst, SE-17176 Stockholm, Sweden

[2] Brigham & Womens Hosp, Leducq Transatlantic Network Excellence Cardiovas, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Donald W Reynolds Cardiovasc Clin Res Ctr, Boston, MA 02115 USA

来源：

CLINICAL IMMUNOLOGY | 2010年 / 134卷 / 01期

关键词：

Atherosclerosis; T cells; Th1; Th2; Regulatory T cells; Costimulation; Coinhibition; Pro-inflammatory cytokines; Anti-inflammatory cytokines; Statins; SMOOTH-MUSCLE-CELLS; GROWTH-FACTOR-BETA; COA REDUCTASE INHIBITORS; RECEPTOR-DEFICIENT MICE; REGULATORY T-CELLS; CHOLESTEROL-INDUCED ATHEROSCLEROSIS; CXC CHEMOKINE RECEPTOR-5; INTERFERON-GAMMA; IFN-GAMMA; REDUCES ATHEROSCLEROSIS;

D O I：

10.1016/j.clim.2009.07.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity and T cells in particular regulate the magnitude of the atherogenic pro-inflammatory response. T cells also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical outcome of disease. This review summarizes our current understanding of T cells in atherogenesis, including which antigens they recognize, the rote of T cell costimulation/coinhibition, and their secretion of pro- and anti-inflammatory mediators. Furthermore, we outline future areas of research and potential clinical intervention strategies. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：33 / 46

页数：14

共 161 条

[21] The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/-mice [J].

Daugherty, A ;

Pure, E ;

DelfelButteiger, D ;

Chen, S ;

Leferovich, J ;

Roselaar, SE ;

Rader, DJ .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (06) :1575-1580

[22] The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice [J].

Davenport, P ;

Tipping, PG .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (03) :1117-1125

[23] Patients with acute coronary syndrome show oligoclonal T-cell recruitment within unstable plaque -: Evidence for a local, intracoronary immunologic mechanism [J].

De Palma, R ;

Del Galdo, F ;

Abbate, G ;

Chiariello, M ;

Calabró, R ;

Forte, L ;

Cimmino, G ;

Papa, MF ;

Russo, MG ;

Ambrosio, G ;

Giombolini, C ;

Tritto, I ;

Notaristefano, S ;

Berrino, L ;

Rossi, F ;

Golino, P .

CIRCULATION, 2006, 113 (05) :640-646

[24] Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation [J].

deBoer, OJ ;

Hirsch, F ;

vanderWal, AC ;

vanderLoos, CM ;

Das, PK ;

Becker, AE .

ATHEROSCLEROSIS, 1997, 133 (02) :227-234

[25] CYCLOSPORINE TREATMENT REDUCES EARLY ATHEROSCLEROSIS IN THE CHOLESTEROL-FED RABBIT [J].

DREW, AF ;

TIPPING, PG .

ATHEROSCLEROSIS, 1995, 116 (02) :181-189

[26] Expression of toll-like receptors in human atherosclerotic lesions - A possible pathway for plaque activation [J].

Edfeldt, K ;

Swedenborg, J ;

Hansson, GK ;

Yan, ZQ .

CIRCULATION, 2002, 105 (10) :1158-1161

[27] Interleukin-17 and Interferon-γ Are Produced Concomitantly by Human Coronary Artery-Infiltrating T Cells and Act Synergistically on Vascular Smooth Muscle Cells [J].

Eid, Raymond E. ;

Rao, Deepak A. ;

Zhou, Jing ;

Lo, Sheng-Fu L. ;

Ranjbaran, Hooman ;

Gallo, Amy ;

Sokol, Seth I. ;

Pfau, Steven ;

Pober, Jordan S. ;

Tellides, George .

CIRCULATION, 2009, 119 (10) :1424-1432

[28] Deleting TCRαβ+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice [J].

Elhage, R ;

Gourdy, P ;

Brouchet, L ;

Jawien, J ;

Fouque, MJ ;

Fiévet, C ;

Huc, X ;

Barreira, Y ;

Couloumiers, JC ;

Arnal, JF ;

Bayard, F .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 165 (06) :2013-2018

[29] Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice [J].

Elhage, R ;

Jawien, J ;

Rudling, M ;

Ljunggren, HG ;

Takeda, K ;

Akira, S ;

Bayard, F ;

Hansson, GK .

CARDIOVASCULAR RESEARCH, 2003, 59 (01) :234-240

[30]

EMESON EE, 1993, AM J PATHOL, V142, P1906

← 1 2 3 4 5 6 7 8 9 10 →