A splice variant of Dp71 lacking the syntrophin binding site is expressed in early stages of human neural development

被引:25
作者
Ceccarini, M [1 ]
Rizzo, G [1 ]
Rosa, G [1 ]
Chelucci, C [1 ]
Macioce, P [1 ]
Petrucci, TC [1 ]
机构
[1] IST SUPER SANITA,LAB EMATOL ONCOL,I-00161 ROME,ITALY
来源
DEVELOPMENTAL BRAIN RESEARCH | 1997年 / 103卷 / 01期
关键词
apo-dystrophin; 1; Dp71; nervous system development; alternative splicing; Duchenne muscular dystrophy; (human);
D O I
10.1016/S0165-3806(97)00122-3
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Dp71, a 71 kDa C-terminal isoform of dystrophin, is the major product of the DMD gene in brain. Two alternatively spliced transcripts of Dp71 were amplified by RT-PCR from different areas of human fetal neural tissue. Both transcripts were spliced out of exons 71 and 78. The shorter transcript was also alternatively spliced of exons 72-74, a region comprising the coding sequence for the binding site to syntrophin, one component of the dystrophin-associated protein complex. Results indicate that alternatively spliced forms of Dp71 are regulated during human neural development. (C) 1997 Elsevier Science B.V.
引用
收藏
页码:77 / 82
页数:6
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