THE ROLE OF MICROBIOTA IN DEPRESSION - A BRIEF REVIEW

被引：78

作者：

Zalar, Bojan ^{[1
]}

Haslberger, Alexander ^{[2
]}

Peterlin, Borut ^{[3
]}

机构：

[1] Univ Psychiat Clin Ljubljana, Ljubljana, Slovenia

[2] Univ Vienna, Dept Nutr Sci, Vienna, Austria

[3] Univ Med Ctr Ljubljana, Clin Inst Med Genet, Slajmerjeva 4, Ljubljana 1000, Slovenia

来源：

PSYCHIATRIA DANUBINA | 2018年 / 30卷 / 02期

关键词：

depression; microbiota; translation; GUT MICROBIOTA; FECAL MICROBIOTA; BRAIN; BEHAVIOR; EXPRESSION; RECEPTORS; BACTERIA; ANXIETY; RATS;

D O I：

10.24869/psyd.2018.136

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

The microbiota-gut-brain axis is a bidirectional homeostatic route of communication between both of the organs direct via receptors of the CNS or via epigenetic mechanisms of divers metabolites e.g. SCFA, GABA, beta-hydroxybutyrate. Thus, a modulation of gut microbiota via nutrition, lifestyle etc. might be effective for emotional status and depressive disorders. The dietary composition has an influence on gut microbiota composition, microbial metabolite profile and the according consequences on emotional status and depression within a system biologic approach. There are changes in gut microbiota composition and gut microbial profile (butyrate, GABA, beta-hydroxybutyrate) effecting epigenetic regulation (histone acetylation, DNA methylation) and gene expression of receptors and mediators (SLC6A4, BDNF, GABA, GPRs) involved in depressive disorders.

引用

页码：136 / 141

页数：6

共 42 条

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Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms [J].