The promise of circulating tumor cell analysis in cancer management

被引：47

作者：

Mateo, Joaquin ^{[1
,2
,3
]}

Gerlinger, Marco ^{[4
,5
]}

Rodrigues, Daniel Nava ^{[1
,2
,3
]}

de Bono, Johann S. ^{[1
,2
,3
]}

机构：

[1] Inst Canc Res, Div Canc Therapeut, Sutton SM2 5NG, Surrey, England

[2] Inst Canc Res, Div Clin Studies, Sutton SM2 5NG, Surrey, England

[3] Royal Marsden NHS Fdn Trust, Drug Dev Unit, Sutton SM2 5PT, Surrey, England

[4] Inst Canc Res, Ctr Evolut & Canc, London SW7 3RP, England

[5] Royal Marsden NHS Fdn Trust, Dept Med, Gastrointestinal Canc Unit, London SW3 6JJ, England

来源：

GENOME BIOLOGY | 2014年 / 15卷 / 08期

关键词：

METASTATIC BREAST-CANCER; RESISTANT PROSTATE-CANCER; PERIPHERAL-BLOOD; INTRATUMOR HETEROGENEITY; MOLECULAR EVOLUTION; ACQUIRED-RESISTANCE; PROGNOSTIC VALUE; LUNG-CANCER; END-POINTS; SURVIVAL;

D O I：

10.1186/s13059-014-0448-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Enumeration and molecular characterization of circulating tumor cells isolated from peripheral blood of patients with cancer can aid selection of targeted therapy for patients, monitoring of response to therapies and optimization of drug development, while also providing valuable information about intratumoral heterogeneity.

引用

页数：10

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