CRM1-mediated nuclear export: to the pore and beyond

被引：305

作者：

Hutten, Saskia ^{[1
]}

Kehlenbach, Ralph H. ^{[1
]}

机构：

[1] Univ Gottingen, Zentrum Biochem & Mol Zellbiol, D-37073 Gottingen, Germany

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 04期

关键词：

D O I：

10.1016/j.tcb.2007.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs. Besides its established role in nuclear export, CRM1 is also implicated in various steps during mitosis, widening its functional spectrum within the cell.

引用

页码：193 / 201

页数：9

共 88 条

[1] HIGHER-ORDER CHROMOSOME STRUCTURE IS AFFECTED BY COLD-SENSITIVE MUTATIONS IN A SCHIZOSACCHAROMYCES-POMBE GENE CRM1+ WHICH ENCODES A 115-KD PROTEIN PREFERENTIALLY LOCALIZED IN THE NUCLEUS AND AT ITS PERIPHERY [J].

ADACHI, Y ;

YANAGIDA, M .

JOURNAL OF CELL BIOLOGY, 1989, 108 (04) :1195-1207

[2] Nuclear export of signal recognition particle RNA in mammalian cells [J].

Alavian, CN ;

Politz, JCR ;

Lewandowski, LB ;

Power, CM ;

Pederson, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 313 (02) :351-355

[3] Comparison of ARM and HEAT protein repeats [J].

Andrade, MA ;

Petosa, C ;

O'Donoghue, SI ;

Müller, CW ;

Bork, P .

JOURNAL OF MOLECULAR BIOLOGY, 2001, 309 (01) :1-18

[4] Crm1 is a mitotic effector of Ran-GTP in somatic cells [J].

Arnaoutov, A ;

Azuma, Y ;

Ribbeck, K ;

Joseph, J ;

Boyarchuk, Y ;

Karpova, T ;

McNally, J ;

Dasso, M .

NATURE CELL BIOLOGY, 2005, 7 (06) :626-U27

[5]

Askjaer P, 1999, MOL CELL BIOL, V19, P6276

[6] Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1 [J].

Benzeno, S. ;

Lu, F. ;

Guo, M. ;

Barbash, O. ;

Zhang, F. ;

Herman, J. G. ;

Klein, P. S. ;

Rustgi, A. ;

Diehl, J. A. .

ONCOGENE, 2006, 25 (47) :6291-6303

[7] Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein export [J].

Bernad, R ;

van der Velde, H ;

Fornerod, M ;

Pickersgill, H .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (06) :2373-2384

[8] Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export [J].

Bernad, Rafael ;

Engelsma, Dieuwke ;

Sanderson, Helen ;

Pickersgill, Helen ;

Fornerod, Maarten .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (28) :19378-19386

[9] NXT1 is necessary for the terminal step of Crm1-mediated nuclear export [J].

Black, BE ;

Holaska, JM ;

Lévesque, L ;

Ossareh-Nazari, B ;

Gwizdek, C ;

Dargemont, C ;

Paschal, BM .

JOURNAL OF CELL BIOLOGY, 2001, 152 (01) :141-155

[10] PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli [J].

Boulon, S ;

Verheggen, C ;

Jady, BE ;

Girard, C ;

Pescia, C ;

Paul, C ;

Ospina, JK ;

Kiss, T ;

Matera, AG ;

Bordonné, M ;

Bertrand, E .

MOLECULAR CELL, 2004, 16 (05) :777-787

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