CRM1-mediated nuclear export: to the pore and beyond

被引：305

作者：

Hutten, Saskia ^{[1
]}

Kehlenbach, Ralph H. ^{[1
]}

机构：

[1] Univ Gottingen, Zentrum Biochem & Mol Zellbiol, D-37073 Gottingen, Germany

来源：

TRENDS IN CELL BIOLOGY | 2007年 / 17卷 / 04期

关键词：

D O I：

10.1016/j.tcb.2007.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs. Besides its established role in nuclear export, CRM1 is also implicated in various steps during mitosis, widening its functional spectrum within the cell.

引用

页码：193 / 201

页数：9

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