Substituted guanidines: Introducing diversity in combinatorial chemistry

被引：30

作者：

del Fresno, M

El-Faham, A

Carpino, LA

Royo, M

Albericio, F ^{[1
]}

机构：

[1] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

[2] Univ Alexandria, Fac Sci, Dept Chem, Alexandria 2132, Egypt

[3] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 23期

关键词：

D O I：

10.1021/ol006322p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The guanidine moiety is an important motif present in many biologically active compounds. Fully substituted guanidines are of key importance for the development of bioactive molecules. The present paper reports on an efficient procedure for the direct solid phase conversion of amines to fully substituted guanidines under very mild conditions.

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页码：3539 / 3542

页数：4

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