A pincer auxiliary to force difficult lactamisations

被引:21
作者
Bieräugel, H
Schoemaker, HE
Hiemstra, H
van Maarseveen, JH
机构
[1] Univ Amsterdam, Inst Mol Chem, NL-1018 WS Amsterdam, Netherlands
[2] DSM Res & Patents, Life Sci Prod, NL-6160 MD Geleen, Netherlands
关键词
D O I
10.1039/b303836j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new method to cyclise peptides is reported based on insertion of a salicylaldehyde derived pincer auxiliary in the linear precursor sequence. H-betaAla-Phe-OH and H-PhebetaAla- OH were chosen as representative model peptides.
引用
收藏
页码:1830 / 1832
页数:3
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