A novel strategy for the synthesis of medium-sized lactams

被引：56

作者：

Bieräugel, H

Jansen, TP

Schoemaker, HE

Hiemstra, H

van Maarseveen, JH

机构：

[1] Univ Amsterdam, Inst Mol Chem, NL-1018 WS Amsterdam, Netherlands

[2] DSM Res & Patents, Life Sci Prod, NL-6160 MD Geleen, Netherlands

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 16期

关键词：

D O I：

10.1021/ol0261579

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A novel method for the synthesis of medium-sized lecterns based on an auxiliary-mediated combined tethered/templated strategy is presented. Cyclization by a tethered ring-closing metathesis reaction was followed by a templated transannular aminolysis reaction to give seven- to ten-membered lecterns in good yields.

引用

收藏

页码：2673 / 2674

页数：2

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