THE N-(2-HYDROXYBENZYL) PROTECTING GROUP FOR AMIDE BOND PROTECTION IN SOLID-PHASE PEPTIDE-SYNTHESIS

被引：22

作者：

JOHNSON, T

QUIBELL, M

机构：

[1] Laboratory of Molecular Biology, Medical Research Council, Cambridge, CB2 2QH, Hills Road

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 03期

关键词：

D O I：

10.1016/0040-4039(94)85081-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Backbone amide protection using the N-(2-hydroxybenzyl) group to overcome chain aggregation during solid phase peptide synthesis is described. This is illustrated by the preparation of the notoriously difficult decapeptide acyl carrier protein (65-74). The N-(2-hydroxybenzyl) group is stable to trifluoroacetic acid/dichloromethane (1:1, v/v) but cleaved readily by trifluoromethanesulphonic acid.

引用

页码：463 / 466

页数：4

共 15 条

[1]

Atherton E., 1985, PEPTIDES STRUCTURE F, P415

[2]

BEDFORD J, 1992, INT J PEPT PROT RES, V40, P300

[3] PEPTIDE-SYNTHESIS .8. A SYSTEM FOR SOLID-PHASE SYNTHESIS UNDER LOW-PRESSURE CONTINUOUS-FLOW CONDITIONS [J].