INTERNAL AGGREGATION DURING SOLID-PHASE PEPTIDE-SYNTHESIS - DIMETHYL-SULFOXIDE AS A POWERFUL DISSOCIATING SOLVENT

被引：57

作者：

HYDE, C

JOHNSON, T

SHEPPARD, RC

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 21期

关键词：

D O I：

10.1039/c39920001573

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Internal aggregation within the peptide-resin matrix during solid phase peptide synthesis may be overcome by the use of dimethyl sulfoxide as solvent for both acylation and deprotection reactions.

引用

页码：1573 / 1575

页数：3

共 17 条

[1]

Atherton E, 1989, SOLID PHASE PEPTIDE

[2]

Atherton E., 1985, PEPTIDES STRUCTURE F, P415

[3]

BEDFORD J, 1992, IN PRESS INT J PEPTI

[4]

BEDFORD J, 1991, IN PRESS 2ND P INT C

[5]

DEMILTON RCL, 1990, J AM CHEM SOC, V112, P6039

[6] SOLVATION EFFECTS IN SOLID-PHASE PEPTIDE-SYNTHESIS [J].

FIELDS, GB ;

FIELDS, CG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (11) :4202-4207

[7]

FIELDS GB, 1990, INNOVATION PERSPECTI, P241

[8] STUDIES RELATED TO A CONVERGENT FRAGMENT-COUPLING APPROACH TO PEPTIDE-SYNTHESIS USING THE KAISER OXIME RESIN [J].

HENDRIX, JC ;

JARRETT, JT ;

ANISFELD, ST ;

LANSBURY, PT .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (12) :3414-3420

[9]

KEMP DS, 1973, PEPTIDES 1971, P1

[10]

KENT SBH, 1985, PEPTIDES STRUCTURE F, P00407

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