INTERNAL AGGREGATION DURING SOLID-PHASE PEPTIDE-SYNTHESIS - DIMETHYL-SULFOXIDE AS A POWERFUL DISSOCIATING SOLVENT

被引：57

作者：

HYDE, C

JOHNSON, T

SHEPPARD, RC

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 21期

关键词：

D O I：

10.1039/c39920001573

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Internal aggregation within the peptide-resin matrix during solid phase peptide synthesis may be overcome by the use of dimethyl sulfoxide as solvent for both acylation and deprotection reactions.

引用

页码：1573 / 1575

页数：3

共 17 条

[11] MASS-SPECTROMETRIC EVALUATION OF SYNTHETIC PEPTIDES FOR DELETIONS AND INSERTIONS [J].

MERRIFIELD, RB ;

SINGER, J ;

CHAIT, BT .

ANALYTICAL BIOCHEMISTRY, 1988, 174 (02) :399-414

[12]

NGUYEN O, 1989, 20TH P EUR PEPT S TU, P151

[13]

RAPP W, COMMUNICATION

[14]

Stewart J. W., 1990, INNOVATIONS PERSPECT, P1

[15] LITHIUM-SALT EFFECTS IN PEPTIDE-SYNTHESIS .2. IMPROVEMENT OF DEGREE OF RESIN SWELLING AND OF EFFICIENCY OF COUPLING IN SOLID-PHASE SYNTHESIS [J].

THALER, A ;

SEEBACH, D ;

CARDINAUX, F .

HELVETICA CHIMICA ACTA, 1991, 74 (03) :628-643

[16] LITHIUM-SALT EFFECTS IN PEPTIDE-SYNTHESIS .1. CONDITIONS FOR THE USE OF LITHIUM-SALTS IN COUPLING REACTIONS [J].

THALER, A ;

SEEBACH, D ;

CARDINAUX, F .

HELVETICA CHIMICA ACTA, 1991, 74 (03) :617-627

[17]

VANWOERKOM WJ, 1991, INT J PEPT PROT RES, V38, P103

← 1 2 →