Common variation in genes involved in HDL metabolism influences coronary heart disease risk at the population level

被引：5

作者：

Brousseau, ME ^{[1
]}

机构：

[1] Tufts Univ, Lipid Metab Lab, JM USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[2] Tufts Univ New England Med Ctr, Dept Med, Boston, MA 02111 USA

来源：

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2004年 / 5卷 / 04期

关键词：

ATP-binding cassette transporter A1; cholesteryl ester transfer protein; high density lipoproteins; polymorphism;

D O I：

10.1023/B:REMD.0000045106.90301.26

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The majority of data support the concept that common variation in the genes encoding ABCA1 and CETP is associated with variation in plasma HDL-C concentrations and/or CHD risk at the population level. Polymorphisms in ABCA1, in particular the R219K variant, appear to influence CHD risk, independent of plasma HDL-C levels. In contrast, CETP polymorphisms that are generally associated with reduced CHD risk, such as the TaqIB variant, are also associated with increased HDL-C levels.

引用

页码：343 / 349

页数：7

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