One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using lanthanum chloride as a catalyst

被引：378

作者：

Lu, J ^{[1
]}

Bai, YJ ^{[1
]}

Wang, ZJ ^{[1
]}

Yang, BQ ^{[1
]}

Ma, HR ^{[1
]}

机构：

[1] NW Univ Xian, Dept Chem, Xian 710069, Peoples R China

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 47期

关键词：

Biginelli reaction; dihydropyrimidinones; lanthanum chloride heptahydrate; one-pot condensation; synthesis;

D O I：

10.1016/S0040-4039(00)01645-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidinones using lanthanum chloride heptahydrate as a catalyst from an aldehyde, beta -keto ester and urea or thiourea in ethanol is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of good yields (56-97%). (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9075 / 9078

页数：4

共 32 条

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