Modulating risky decision-making in Parkinson's disease by transcranial direct current stimulation

被引：18

作者：

Benussi, A. ^{[1
]}

Alberici, A. ^{[1
]}

Cantoni, V. ^{[1
,2
]}

Manenti, R. ^{[3
]}

Brambilla, M. ^{[3
]}

Dell'Era, V. ^{[1
]}

Gazzina, S. ^{[1
]}

Manes, M. ^{[1
]}

Cristillo, V. ^{[1
]}

Padovani, A. ^{[1
]}

Cotelli, M. ^{[3
]}

Borroni, B. ^{[1
]}

机构：

[1] Univ Brescia, Neurol Unit, Dept Clin & Expt Sci, Brescia, Italy

[2] Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

[3] IRCCS Ctr San Giovanni Dio Fatebenefratelli, Neuropsychol Unit, Brescia, Italy

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2017年 / 24卷 / 05期

关键词：

dorsolateral prefrontal cortex; Parkinson's disease; pathological gambling; transcranial direct current stimulation; IOWA GAMBLING TASK; IMPULSE CONTROL DISORDERS; PREFRONTAL CORTEX; MEDICATION;

D O I：

10.1111/ene.13286

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background and purposePerformance on gambling tasks in Parkinson's disease (PD) is of particular interest, as pathological gambling is often associated with dopamine replacement therapy in these patients. We aimed to evaluate the effects of transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (DLPFC) in modulating gambling behaviour in PD. MethodsWe assessed the effects of cathodal tDCS over the right DLPFC during the Iowa Gambling Task in 20 patients with PD, compared with sham stimulation. We then conducted a second experimental design, assessing the effects of anodal tDCS over the right DLPFC. ResultsWe observed that cathodal tDCS over the right DLPFC increased Iowa Gambling Task scores compared with sham stimulation. In the second experimental design, we did not find significant differences between anodal and sham tDCS. ConclusionsCathodal tDCS over the right DLPFC possibly reduces the pathological overdrive in frontostriatal networks in patients with PD on dopaminergic medication, thus modulating impulsive and risky decision-making.

引用

页码：751 / 754

页数：4

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