The genetics of ageing

被引：2033

作者：

Kenyon, Cynthia J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

来源：

NATURE | 2010年 / 464卷 / 7288期

关键词：

LIFE-SPAN EXTENSION; RESTRICTION-INDUCED LONGEVITY; DIETARY RESTRICTION; CAENORHABDITIS-ELEGANS; C; ELEGANS; CALORIE RESTRICTION; MEDIATES LONGEVITY; SIGNALING PATHWAY; AUTOPHAGY GENES; INSULIN;

D O I：

10.1038/nature08980

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly, this means that over evolutionary time mutations have increased lifespan more than 2,000-fold. Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions.

引用

页码：504 / 512

页数：9

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