RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus

被引：79

作者：

O'Neill, A

Oliva, B

Storey, C

Hoyle, A

Fishwick, C

Chopra, I ^{[1
]}

机构：

[1] Univ Leeds, Antimicrobial Res Ctr, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Div Microbiol, Leeds LS2 9JT, W Yorkshire, England

[3] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[4] Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 11期

关键词：

D O I：

10.1128/AAC.44.11.3163-3166.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A collection of rifampin-resistant mutants of Staphylococcus aureus with characterized RNA polymerase beta -subunit (rpoB) gene mutations was cross-screened against a number of other RNA polymerase inhibitors to correlate susceptibility with specific rpoB genotypes. The rpoB mutants were cross-resistant to streptolydigin and sorangicin A. In contrast, thiolutin, holomycin, corallopyronin A, and ripostatin A retained activity against the rpoB mutants. The second group of inhibitors may be of interest as drug development candidates.

引用

页码：3163 / 3166

页数：4

共 30 条

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