Monodisperse magnetic nanoparticles for biodetection, imaging, and drug delivery: a versatile and evolving technology

被引：177

作者：

Dave, Shivang R. ^{[1
]}

Gao, Xiaohu ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2009年 / 1卷 / 06期

基金：

美国国家科学基金会;

关键词：

IRON-OXIDE NANOPARTICLES; NEPHROGENIC SYSTEMIC FIBROSIS; SEMICONDUCTOR QUANTUM DOTS; BARCODE AMPLIFICATION ASSAY; NONVIRAL GENE-TRANSFER; NEURAL STEM-CELLS; IN-VIVO TRACKING; CONTRAST AGENT; SUPERPARAMAGNETIC NANOPARTICLES; FEPT NANOPARTICLES;

D O I：

10.1002/wnan.51

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Advances in nanotechnology have pushed forward the synthesis of a variety of functional nanoparticles (NPs) such as semiconductor quantum dots (QDs), magnetic and metallic NPs. The unique electronic, magnetic, and optical properties exhibited by these nanometer-sized materials have enabled a broad spectrum of biomedical applications. In particular, iron-oxide-based magnetic NPs have proved to be highly versatile deep-tissue imaging agents, having been incorporated into clinical applications due to their biocompatibility. This Interdisciplinary Review will focus on the recent advances in strategies for the synthesis and surface modification of highly monodisperse magnetic NPs and their use in imaging, drug delivery, and innovative ultrasensitive bioassays. (C) 2009 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2009 1 583-609

引用

页码：583 / 609

页数：27

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