Monodisperse magnetic nanoparticles for biodetection, imaging, and drug delivery: a versatile and evolving technology

被引：177

作者：

Dave, Shivang R. ^{[1
]}

Gao, Xiaohu ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2009年 / 1卷 / 06期

基金：

美国国家科学基金会;

关键词：

IRON-OXIDE NANOPARTICLES; NEPHROGENIC SYSTEMIC FIBROSIS; SEMICONDUCTOR QUANTUM DOTS; BARCODE AMPLIFICATION ASSAY; NONVIRAL GENE-TRANSFER; NEURAL STEM-CELLS; IN-VIVO TRACKING; CONTRAST AGENT; SUPERPARAMAGNETIC NANOPARTICLES; FEPT NANOPARTICLES;

D O I：

10.1002/wnan.51

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Advances in nanotechnology have pushed forward the synthesis of a variety of functional nanoparticles (NPs) such as semiconductor quantum dots (QDs), magnetic and metallic NPs. The unique electronic, magnetic, and optical properties exhibited by these nanometer-sized materials have enabled a broad spectrum of biomedical applications. In particular, iron-oxide-based magnetic NPs have proved to be highly versatile deep-tissue imaging agents, having been incorporated into clinical applications due to their biocompatibility. This Interdisciplinary Review will focus on the recent advances in strategies for the synthesis and surface modification of highly monodisperse magnetic NPs and their use in imaging, drug delivery, and innovative ultrasensitive bioassays. (C) 2009 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2009 1 583-609

引用

页码：583 / 609

页数：27

共 199 条

[71] Designed fabrication of a multifunctional polymer nanomedical platform for simultaneous cancer-targeted imaging and magnetically guided drug delivery [J].

Kim, Jaeyun ;

Lee, Ji Eun ;

Lee, Soo Hyeon ;

Yu, Jung Ho ;

Lee, Jung Hee ;

Park, Tae Gwan ;

Hyeon, Taeghwan .

ADVANCED MATERIALS, 2008, 20 (03) :478-+

[72] Designed fabrication of multifunctional magnetic gold nanoshells and their application to magnetic resonance imaging and photothermal therapy [J].

Kim, Jaeyun ;

Park, Sungjin ;

Lee, Ji Ean ;

Jin, Seung Min ;

Lee, Jung Hee ;

Lee, In Su ;

Yang, Ilseung ;

Kim, Jun-Sung ;

Kim, Seong Keun ;

Cho, Myung-Haing ;

Hyeon, Taeghwan .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (46) :7754-7758

[73] Magnetic force-based multiplexed immunoassay using superparamagnetic nanoparticles in microfluidic channel [J].

Kim, KS ;

Park, JK .

LAB ON A CHIP, 2005, 5 (06) :657-664

[74] In vivo monitoring of macrophage infiltration in experimental ischemic brain lesions by magnetic resonance imaging [J].

Kleinschnitz, C ;

Bendszus, T ;

Frank, M ;

Solymosi, T ;

Toyka, KV ;

Stoll, G .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2003, 23 (11) :1356-1361

[75] Determination of the binding reaction between avidin and biotin by relaxation measurements of magnetic nanoparticles [J].

Kötitz, R ;

Weitschies, W ;

Trahms, L ;

Brewer, W ;

Semmler, W .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1999, 194 (1-3) :62-68

[76] In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction [J].

Kraitchman, DL ;

Heldman, AW ;

Atalar, E ;

Amado, LC ;

Martin, BJ ;

Pittenger, MF ;

Hare, JM ;

Bulte, JWM .

CIRCULATION, 2003, 107 (18) :2290-2293

[77] Nanomagnetism and spin electronics: materials, microstructure and novel properties [J].

Krishnan, KM ;

Pakhomov, AB ;

Bao, Y ;

Blomqvist, P ;

Chun, Y ;

Gonzales, M ;

Griffin, K ;

Ji, X ;

Roberts, BK .

JOURNAL OF MATERIALS SCIENCE, 2006, 41 (03) :793-815

[78] Magnetofection -: A highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo [J].

Krötz, F ;

de Wit, C ;

Sohn, HY ;

Zahler, S ;

Gloe, T ;

Pohl, U ;

Plank, C .

MOLECULAR THERAPY, 2003, 7 (05) :700-710

[79] Magnetofection potentiates gene delivery to cultured endothelial cells [J].

Krötz, F ;

Sohn, HY ;

Gloe, T ;

Plank, C ;

Pohl, U .

JOURNAL OF VASCULAR RESEARCH, 2003, 40 (05) :425-434

[80] Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties [J].

Kumar, S. ;

Aaron, J. ;

Sokolov, K. .

NATURE PROTOCOLS, 2008, 3 (02) :314-320

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