Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria

被引：41

作者：

Zorov, Dmitry B. ^{[1
,2
]}

机构：

[1] Moscow MV Lomonosov State Univ, AN Belozersky Inst Physicochem Biol, Dept Bioenerget, Moscow 119991, Russia

[2] NIA, Cardiovasc Sci Lab, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA

来源：

KIDNEY INTERNATIONAL | 2010年 / 77卷 / 10期

关键词：

PERMEABILITY TRANSITION;

D O I：

10.1038/ki.2010.20

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cytotoxic effects of some therapeutic drugs, including those used for antibacterial treatment, can involve mitochondria by inducing their permeabilization, followed by cell death and organ malfunctioning. This suggests that a strategy to preserve tissue mitochondria could preserve normal organ functioning. Morales et al. reveal that the antidiabetic drug metformin prevents gentamicin-induced nephropathy through a mitochondria-dependent pathway, normalizing oxidative stress and restoring mitochondrial functional integrity. Kidney International (2010) 77, 841-843. doi:10.1038/ki.2010.20

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收藏

页码：841 / 843

页数：3

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