Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans

被引：259

作者：

Chondronikola, Maria ^{[1
,2
,3
,4
]}

Volpi, Elena ^{[3
,5
,6
,7
]}

Borsheim, Elisabet ^{[1
,8
]}

Porter, Craig ^{[1
,8
]}

Saraf, Manish K. ^{[1
,8
]}

Annamalai, Palam ^{[9
]}

Yfanti, Christina ^{[1
,6
]}

Chao, Tony ^{[1
,2
,3
]}

Wong, Daniel ^{[10
,11
]}

Shinoda, Kosaku ^{[10
,11
]}

Labbe, Sebastien M. ^{[12
]}

Hurren, Nicholas M. ^{[1
,8
]}

Cesani, Fernardo ^{[13
]}

Kajimura, Shingo ^{[10
,11
]}

Sidossis, Labros S. ^{[1
,3
,4
,5
,6
,7
,14
,15
]}

机构：

[1] Shriners Hosp Children, Metab Unit, Galveston, TX 77555 USA

[2] Univ Texas Med Branch, Dept Prevent Med & Community Hlth, Galveston, TX 77555 USA

[3] Univ Texas Med Branch, Div Rehabil Sci, Dept Nutr & Metab, Galveston, TX 77555 USA

[4] Harokopio Univ Athens, Dept Nutr & Dietet, Athens 17671, Greece

[5] Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA

[6] Univ Texas Med Branch, Sealy Ctr Aging, Galveston, TX 77555 USA

[7] Univ Texas Med Branch, Dept Internal Med, Galveston, TX 77555 USA

[8] Univ Texas Med Branch, Dept Surg, Galveston, TX 77555 USA

[9] Univ Texas Med Branch, Dept Intervent Radiol, Galveston, TX 77555 USA

[10] Univ Calif San Francisco, Dept Cell & Tissue Biol, Ctr Diabet, San Francisco, CA 94143 USA

[11] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA

[12] Quebec Heart & Lung Res Inst Ctr, Ste Foy, PQ G1V 4G5, Canada

[13] Univ Texas Med Branch, Dept Nucl Med, Galveston, TX 77555 USA

[14] Rutgers State Univ, Dept Exercise Sci, New Brunswick, NJ 08901 USA

[15] Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Med, New Brunswick, NJ 08901 USA

来源：

CELL METABOLISM | 2016年 / 23卷 / 06期

基金：

美国国家卫生研究院;

关键词：

INSULIN SENSITIVITY; ADULT HUMANS; GLUCOSE-HOMEOSTASIS; OBESE SUBJECTS; COLD-EXPOSURE; HEALTHY-MEN; RESISTANCE; LEPTIN; FAT; RESPONSES;

D O I：

10.1016/j.cmet.2016.04.029

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies suggest that brown adipose tissue (BAT) plays a role in energy and glucose metabolism in humans. However, the physiological significance of human BAT in lipid metabolism remains unknown. We studied 16 overweight/obese men during prolonged, non-shivering cold and thermoneutral conditions using stable isotopic tracer methodologies in conjunction with hyperinsulinemic-euglycemic clamps and BAT and white adipose tissue (WAT) biopsies. BAT volume was significantly associated with increased whole-body lipolysis, triglyceride-free fatty acid (FFA) cycling, FFA oxidation, and adipose tissue insulin sensitivity. Functional analysis of BAT and WAT demonstrated the greater thermogenic capacity of BAT compared to WAT, while molecular analysis revealed a cold-induced upregulation of genes involved in lipid metabolism only in BAT. The accelerated mobilization and oxidation of lipids upon BAT activation supports a putative role for BAT in the regulation of lipid metabolism in humans.

引用

页码：1200 / 1206

页数：7

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