In vivo degradation of tungsten embolisation coils

被引:21
作者
Butler, TJ [1 ]
Jackson, RW
Robson, JY
Owen, RJT
Delves, HT
Sieniawska, CE
Rose, JDG
机构
[1] Freeman Rd Hosp, Dept Radiol, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England
[2] Freeman Rd Hosp, Dept Biochem, Newcastle Upon Tyne NE7 7DN, Tyne & Wear, England
[3] Southampton Gen Hosp, Supra Reg Assay Serv, Trace Element Unit, Southampton SO9 4XY, Hants, England
关键词
D O I
10.1259/bjr.73.870.10911782
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
It has been suggested that tungsten embolisation coils in intracranial aneurysms may dissolve in situ. These coils are also used, in much larger quantities, for the occlusion of larger vessels outside the cranium. This study was performed to investigate whether tungsten embolisation coils may become degraded in vivo and to examine whether this is radiographically evident on medium-term follow-up. 10 patients who had undergone aortic stent-graft repair of an abdominal aortic aneurysm (8 male and 2 female, mean age 69.7 years) and 10 age- and sex-matched controls were studied. The study group had also received an average of 64 cm of tungsten coil either to prevent or to treat an endoleak. Whole blood, serum and urine tungsten levels were assayed. Immediate post-operative and follow-up abdominal radiographs were reviewed by two consultant vascular radiologists to detect visible changes in the coils. Whole blood, serum and urine levels of tungsten were highly and significantly elevated (p < 0.001) in the study group compared with the controls. No radiographic changes in the coils were seen at an average of 16.7 months. In conclusion, tungsten embolisation coils dissolve in humans but radiographic changes are not apparent on medium-term follow-up. The clinical significance of these findings is uncertain but long-term follow-up is needed.
引用
收藏
页码:601 / 603
页数:3
相关论文
共 6 条
[1]  
Leggett RW, 1997, SCI TOTAL ENVIRON, V206, P147
[2]   A soldier who had seizures after drinking quarter of a litre of wine [J].
Marquet, P ;
Francois, B ;
Vignon, P ;
Lachatre, G .
LANCET, 1996, 348 (9034) :1070-1070
[3]   TRACE-ELEMENT REFERENCE VALUES IN TISSUES FROM INHABITANTS OF THE EUROPEAN COMMUNITY .1. A STUDY OF 46 ELEMENTS IN URINE, BLOOD AND SERUM OF ITALIAN SUBJECTS [J].
MINOIA, C ;
SABBIONI, E ;
APOSTOLI, P ;
PIETRA, R ;
POZZOLI, L ;
GALLORINI, M ;
NICOLAOU, G ;
ALESSIO, L ;
CAPODAGLIO, E .
SCIENCE OF THE TOTAL ENVIRONMENT, 1990, 95 :89-105
[4]   Trace metals in urine of United States residents: Reference range concentrations [J].
Paschal, DC ;
Ting, BG ;
Morrow, JC ;
Pirkle, JL ;
Jackson, RJ ;
Sampson, EJ ;
Miller, DT ;
Caldwell, KL .
ENVIRONMENTAL RESEARCH, 1998, 76 (01) :53-59
[5]   The determination of metals (antimony, bismuth, lead, cadmium, mercury, palladium, platinum, tellurium, thallium, tin and tungsten) in urine samples by inductively coupled plasma-mass spectrometry [J].
Schramel, P ;
Wendler, I ;
Angerer, J .
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 1997, 69 (03) :219-223
[6]   Corrosion of tungsten spirals. A disturbing finding [J].
Weill, A ;
Ducros, V ;
Cognard, C ;
Piotin, M ;
Moret, J .
INTERVENTIONAL NEURORADIOLOGY, 1998, 4 (04) :337-340