Deletion of the 5′-ABL region:: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients

被引:35
作者
Herens, C
Tassin, F
Lemaire, V
Beguin, Y
Collard, E
Lampertz, S
Croisiau, C
Lecomte, M
De Prijk, B
Longrée, L
Koulischer, L
机构
[1] Univ Liege, CHU, Ctr Human Genet, Dept Human Genet, B-4000 Liege, Belgium
[2] Univ Liege, CHU, Dept Biol Haematol, B-4000 Liege, Belgium
[3] Univ Liege, CHU, Dept Clin Haematol, B-4000 Liege, Belgium
[4] Hop Citadelle, Dept Haematol, Liege, Belgium
[5] Hop Bois Abbaye, Dept Haematol, Seraing, Belgium
[6] Clin St Joseph, Dept Haematol, Liege, Belgium
关键词
chronic myeloid leukaemia; Philadelphia chromosome; BCR-ABL positive; 5 '-ABL deletion; FISH;
D O I
10.1046/j.1365-2141.2000.02142.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration.
引用
收藏
页码:214 / 216
页数:3
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