A fused GaINAc-thiazole from a singular and unanticipated fragmentation

被引：4

作者：

Knapp, S

Amorelli, B

Doss, GA

机构：

[1] Rutgers State Univ, Dept Chem & Chem Biol, Piscataway, NJ 08854 USA

[2] Merck & Co Inc, Rahway, NJ 07065 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 46期

基金：

美国国家卫生研究院;

关键词：

retro-aldol; rearrangement; aromatization;

D O I：

10.1016/j.tetlet.2004.09.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Attempted O-desilylation of an elaborated GalNAc-thiazoline t-butyl ester gave rise instead to a GalNAc-thiazole wherein the two-carbon acetate side chain has been severed by a process heretofore undescribed. The corresponding ether ester rearranged to a C-furanoside by a quite different pathway. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：8507 / 8510

页数：4

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