Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model

被引：149

作者：

Zhu, W

Rawlins, BA

Boachie-Adjei, O

Myers, ER

Arimizu, J

Choi, E

Lieberman, JR

Crystal, RG

Hidaka, C

机构：

[1] Hosp Special Surg, Lab Soft Tissue Res, Musculoskeletal Integr Program, New York, NY 10021 USA

[2] Hosp Special Surg, Dept Orthoped Surg, Spinal Deform Serv, New York, NY 10021 USA

[3] Univ Calif Los Angeles, Dept Orthoped Surg, Los Angeles, CA USA

[4] Cornell Univ, Weill Med Coll, Dept Med Genet, New York, NY USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2004年 / 19卷 / 12期

关键词：

bone morphogenetic protein; osteoblasts; bone; bone mineralization; rodent;

D O I：

10.1359/JBMR.040821

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To enhance the osteogenic activity of BMP, combination BMP2 and BMP7 gene transfer was performed. This approach led to a significant increase in osteoblastic differentiation of mesenchymal precursors compared with single BMP gene transfer in vitro. When tested in 78 rats, combination gene transfer enhanced mechanically stable spine fusion and bone formation rate versus single BMP gene transfer.

引用

页码：2021 / 2032

页数：12

共 74 条

[1] Simple carrier matrix modifications can enhance delivery of recombinant human bone morphogenetic protein-2 for posterolateral spine fusion [J].