Comparative genomic organization of the cbl genes

被引：41

作者：

Nau, MM

Lipkowitz, S

机构：

[1] NCI, Genet Branch, Ctr Canc Res, Natl Naval Med Ctr, Bethesda, MD 20889 USA

[2] Uniformed Serv Univ Hlth Sci, Cell & Mol Biol Program, Bethesda, MD 20889 USA

来源：

GENE | 2003年 / 308卷

关键词：

cbl family; gene evolution;

D O I：

10.1016/S0378-1119(03)00471-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The genomic organization of cbl genes from a variety of mammalian and non-mammalian species was determined by a combination of cloning and database searches. Humans and mice have three cbl genes (c-cbl,(1) cblb, and cblc) which show remarkable conservation of the intron/exon structure over the region of the genes which encode the highly conserved N-terminal region of the proteins including the RING finger. Searches of genomic, cDNA, and EST databases revealed that one or more cbl genes exist in chordates, insects, and worms. Comparison of the complexity and genomic organization of the cbl gene family and the predicted Cbl proteins from various species suggests that the three mammalian cbl genes arose by two duplications of an ancestral gene. The genomic organization of the cbl genes from various species provides insight into the evolution of the cbl gene family. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：103 / 113

页数：11

共 33 条

[1] TUMOR-INDUCTION BY ACTIVATED ABL INVOLVES TYROSINE PHOSPHORYLATION OF THE PRODUCT OF THE CBL ONCOGENE [J].

ANDONIOU, CE ;

THIEN, CBF ;

LANGDON, WY .

EMBO JOURNAL, 1994, 13 (19) :4515-4523

[2] Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes [J].

Aparicio, S ;

Chapman, J ;

Stupka, E ;

Putnam, N ;

Chia, J ;

Dehal, P ;

Christoffels, A ;

Rash, S ;

Hoon, S ;

Smit, A ;

Gelpke, MDS ;

Roach, J ;

Oh, T ;

Ho, IY ;

Wong, M ;

Detter, C ;

Verhoef, F ;

Predki, P ;

Tay, A ;

Lucas, S ;

Richardson, P ;

Smith, SF ;

Clark, MS ;

Edwards, YJK ;

Doggett, N ;

Zharkikh, A ;

Tavtigian, SV ;

Pruss, D ;

Barnstead, M ;

Evans, C ;

Baden, H ;

Powell, J ;

Glusman, G ;

Rowen, L ;

Hood, L ;

Tan, YH ;

Elgar, G ;

Hawkins, T ;

Venkatesh, B ;

Rokhsar, D ;

Brenner, S .

SCIENCE, 2002, 297 (5585) :1301-1310

[3] Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b [J].

Bachmaier, K ;

Krawczyk, C ;

Kozieradzki, I ;

Kong, YY ;

Sasaki, T ;

Oliveira-dos-Santos, A ;

Mariathasan, S ;

Bouchard, D ;

Wakeham, A ;

Itie, A ;

Le, J ;

Ohashi, PS ;

Sarosi, I ;

Nishina, H ;

Lipkowitz, S ;

Penninger, JM .

NATURE, 2000, 403 (6766) :211-216

[4] Isolation and characterization of a novel, transforming allele of the c-Cbl proto-oncogene from a murine macrophage cell line [J].

Bisson, SA ;

Ujack, EE ;

Robbins, SM .

ONCOGENE, 2002, 21 (23) :3677-3687

[5]

BLAKE TJ, 1991, ONCOGENE, V6, P653

[6] Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation [J].

Bustelo, XR ;

Crespo, P ;

LopezBarahona, M ;

Gutkind, JS ;

Barbacid, M .

ONCOGENE, 1997, 15 (21) :2511-2520

[7]

Calin G, 1998, CANCER RES, V58, P3777

[8] Cbl-b regulates the CD28 dependence of T-cell activation [J].

Chiang, YPJ ;

Kole, HK ;

Brown, K ;

Naramura, M ;

Fukuhara, S ;

Hu, RJ ;

Jang, IK ;

Gutkind, JS ;

Shevach, E ;

Gu, H .

NATURE, 2000, 403 (6766) :216-220

[9] Characterization of the mouse Cblc/Cbl3 gene [J].

Fiore, F ;

Ollendorff, V ;

Birnbaum, D .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (01) :182-187

[10] Conservation of long-range synteny and microsynteny between the genomes of two distantly related nematodes [J].

DB Guiliano ;

N Hall ;

SJM Jones ;

LN Clark ;

CH Corton ;

BG Barrell ;

ML Blaxter .

Genome Biology, 3 (10)

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