Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice

被引：16

作者：

Hashimoto, T

Fukunari, A

Yamada, I

Yanaka, N

Chen, D

Kato, N ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biosphere Sci, Higashihiroshima 7398528, Japan

[2] Mitsubishi Pharma Corp, Pharmaceut Res Unit, Yokohama, Kanagawa 2270033, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 01期

关键词：

colon aberrant crypt foci; xanthine oxidase; 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid (Y-700); reactive oxygen species; cell proliferation;

D O I：

10.1271/bbb.69.209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.

引用

页码：209 / 211

页数：3

共 19 条

[1]

Molecular basis of α-tocopherol control of smooth muscle cell proliferation [J].