Role of PD-1 in regulating acute infections

被引：117

作者：

Brown, Keturah E. ^{[1
]}

Freeman, Gordon J. ^{[2
]}

Wherry, E. John ^{[3
]}

Sharpe, Arlene H. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Dept Med Oncol,Dana Farber Canc Ctr, Boston, MA 02115 USA

[3] Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CHRONIC VIRAL-INFECTION; T-CELL DIFFERENTIATION; PROTECTIVE IMMUNITY; MEMORY; EXPRESSION; EFFECTOR; RECEPTOR; LIGANDS; PRECURSOR; BLOCKADE;

D O I：

10.1016/j.coi.2010.03.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated.

引用

页码：397 / 401

页数：5

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