Fluorescent 7-deazapurine derivatives from 5-iodocytosine via a tandem cross-coupling-annulation reaction with terminal alkynes

被引：24

作者：

Hudson, RHE ^{[1
]}

Dambenieks, AK ^{[1
]}

Viirre, RD ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada

来源：

SYNLETT | 2004年 / 13期

关键词：

annulation; cross-coupling; nucleobase; pyrrolocytosine; peptide nucleic acid;

D O I：

10.1055/s-2004-832851

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorescent bicyclic analogs of cytosine have been synthesized directly from derivatives of 5-iodocytosine by a one-pot sequential Sonogashira cross-coupling and annulation with terminal alkynes. The spectral properties of these compounds depend on the identity of the alkyne. 7-Deazapurines synthesized from substituted phenylacetylenes possess greater fluorescence than those derived from alkyl substituted alkynes.

引用

页码：2400 / 2402

页数：3

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