Herpes virus replication

被引:88
作者
Boehmer, PE [1 ]
Nimonkar, AV [1 ]
机构
[1] Univ Miami, Sch Med, Dept Biochem & Mol Biol, Miami, FL 33101 USA
关键词
herpes virus; lytic replication; latency; recombination; initiation; gene expression; ORIGIN-BINDING-PROTEIN; DEPENDENT DNA-REPLICATION; SIMPLEX-VIRUS; TYPE-1; ORIGIN; HUMAN CYTOMEGALOVIRUS; IN-VITRO; COMPLEX-FORMATION; TERMINAL REPEAT; MESSENGER-RNA; GENE-PRODUCT;
D O I
10.1080/1521654031000070645
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Herpesviruses are large double stranded DNA animal viruses with the distinguishing ability to establish latent, life-long infections. To date, eight human herpesviruses that exhibit distinct biological and corresponding pathological/clinical properties have been identified. During their life cycles, herpesviruses execute an intricate chain of events geared towards optimizing their replication. This sets an interesting paradigm to study fundamental biological processes. This review summarizes recent developments in herpesvirus research with emphasis on genome transactions, particularly with respect to the prototypic herpes simplex virus type-1.
引用
收藏
页码:13 / 22
页数:10
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