Mitochondria in HIV-1-induced apoptosis

被引：40

作者：

Arnoult, D ^{[1
]}

Petit, F ^{[1
]}

Lelièvre, JD ^{[1
]}

Estaquier, M ^{[1
]}

机构：

[1] Univ Paris 07, Hop Bichat Claude Bernard, EMI U 9922, INSERM,AP HP, Paris, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 304卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(03)00629-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is now well admitted that HIV infection leading to AIDS is associated with an abnormal susceptibility of T cells to undergo apoptosis. Recent progress in research into programmed cell death has resulted in the identification of the principal pathways involved in this process. Thus the "extrinsic" as well as the "intrinsic" pathways converge to the mitochondria considered as the main sensor of programmed cell death. This review summarizes our knowledge of the influence of mitochondrial control on T cell death during HIV and SIV infections. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：561 / 574

页数：14

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